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The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

Authors :
Eun‐Ran Park
Sang‐Bum Kim
Jee‐San Lee
Yang‐Hyun Kim
Dong‐Hyoung Lee
Eung‐Ho Cho
Sun‐Hoo Park
Chul Ju Han
Bu‐Yeo Kim
Dong Wook Choi
Young Do Yoo
Ami Yu
Jae Won Lee
Ja June Jang
Young Nyun Park
Kyung‐Suk Suh
Kee‐Ho Lee
Source :
Cancer Medicine, Vol 6, Iss 4, Pp 749-760 (2017)
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Abstract Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real‐time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1‐fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan–Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence‐free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the α‐fetoprotein (AFP) level. The patient subgroup with higher AFP levels (≥20 ng/mL) exhibited significant differences in 5‐year overall (18.5% vs. 67.9%) and recurrence‐free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (

Details

Language :
English
ISSN :
20457634
Volume :
6
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Cancer Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.88af73ebc6d7459488be31942aa346fe
Document Type :
article
Full Text :
https://doi.org/10.1002/cam4.1042