Back to Search
Start Over
Unusual Indolent Course of a Chronic Active Epstein-Barr Virus-Associated Natural Killer Cell Lymphoproliferative Disorder
- Source :
- Sultan Qaboos University Medical Journal, Vol 16, Iss 2, Pp 230-233 (2016)
- Publication Year :
- 2016
- Publisher :
- Sultan Qaboos University, 2016.
-
Abstract
- Natural killer (NK) cell lymphoproliferative disorders are uncommon and the Epstein-Barr virus (EBV) plays an important aetiological role in their pathogenesis. We report a 20-year-old male with a chronic active EBV infection associated with a NK cell lymphoproliferative disorder which had an unusual indolent course. He presented to the Sultan Qaboos University Hospital in Muscat, Oman, in December 2011 with a history of intermittent fever and coughing. Examinations revealed generalised lymphadenopathy, hepatosplenomegaly, leukocytosis, transaminitis, diffuse bilateral lung infiltrates and bone marrow lymphocyte involvement. A polymerase chain reaction (PCR) test revealed a high EBV viral load in the peripheral blood cells. The patient received a course of piperacillin-tazobactam for Klebsiella pneumoniae, but no active treatment for the lymphoproliferative disorder. However, his lymphocyte count, serum lactate dehydrogenase and liver enzymes dropped spontaneously. In addition, EBV PCR copies fluctuated and then decreased significantly. He remained clinically asymptomatic over the following four years.
Details
- Language :
- English
- ISSN :
- 2075051X and 20750528
- Volume :
- 16
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Sultan Qaboos University Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.88d1773b67ca42d9b285b9ea6e3154f1
- Document Type :
- article
- Full Text :
- https://doi.org/10.18295/squmj.2016.16.02.015