Back to Search
Start Over
Recommendations for the Appropriate Use of Anti-Inflammatory Drugs in the Era of the Coxibs: Defining the Role of Gastroprotective Agents
- Source :
- Canadian Journal of Gastroenterology, Vol 16, Iss 4, Pp 231-240 (2002)
- Publication Year :
- 2002
- Publisher :
- Hindawi Limited, 2002.
-
Abstract
- Treatment with anti-inflammatory drugs and the analgesic efficacy of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are compromised by a two- to fourfold increased risk of gastrointestinal complications. This increased risk has resulted in an increasing use of the new selective cyclooxygenase-2 inhibitors or coxibs, which, in clinical trials and outcomes studies, reduced gastrointestinal adverse events by 50% to 65% compared with conventional NSAIDs. However, the coxibs are not available to all patients who need them, and NSAIDs are still widely used. Moreover, treatment with a coxib cannot heal pre-existing gastrointestinal lesions, and cotherapy with an anti-secretory drug or mucosal protective agent may be required.
- Subjects :
- Diseases of the digestive system. Gastroenterology
RC799-869
Subjects
Details
- Language :
- English
- ISSN :
- 08357900
- Volume :
- 16
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Canadian Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.893aeffebdb6480085cc6e73cac6acaf
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2002/516092