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Effect of interferon treatment on hearing of patients with chronic Hepatitis C
- Source :
- The Saudi Journal of Gastroenterology, Vol 17, Iss 2, Pp 114-118 (2011)
- Publication Year :
- 2011
- Publisher :
- Wolters Kluwer Medknow Publications, 2011.
-
Abstract
- Background/Aim: Some reports in the literature have linked interferon therapy for the treatment of hepatitis C (HCV) with hearing loss. The aim of this study has been to examine the effects of interferon therapy on hearing of patients treated for HCV. Patients and Methods: Patients were recruited according to preset inclusion criteria from two centers. All patients received standard dose pegylated interferon (PEG-IFN a-2b or a-2a) plus ribavirin (RBV). All patients had pure-tone audiometry (PTA), tympanogram and distortion-product otoacoustic emission (DPOAE) before treatment, three months after initiation of treatment, and three months after completion of treatment. Results: Twenty one patients were prospectively recruited. The mean age was 45.7 years. The male to female ratio was 1.1:1. The mean PTA was 15.9 ± 5.3 before treatment, 17.4 ± 6.1 during treatment and 16.5 ± 5.1 after treatment. The differences between pre and mid, pre and post, as well as mid and post were not significantly different (P>0.05) in all audiological assessments. Conclusions: Our results indicate that PEG-IFN\RBV therapy does not have any impact on the hearing thresholds of patients with HCV.
Details
- Language :
- English
- ISSN :
- 13193767 and 19984049
- Volume :
- 17
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- The Saudi Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.89898480ffeb4c44adc09dc94f4d5c9f
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/1319-3767.77240