D-α-tocopherol polyethylene glycol succinate and Poloxamer 188 modified liposomal chrysin hydrogel for enhanced topical treatment of ultraviolet-induced skin photoaging damage

Chrysin (CHR) has a wide range of pharmacological and physiological activities and low toxicity, however, its clinical application is hampered by its insolubility in water, low intestinal absorption and reduced activity due to rapid carbonylation and metabolism of the hydroxyl groups at positions 5 and 7. Here, we describe a new preparation of CHR-loaded liposomal gel (CHR-Lip-Gel) with good physicochemical stability and efficient antiphotoaging properties. The CHR-loaded liposomes (CHR-Lip) was hybridized with D-α-tocopherol polyethylene glycol succinate and Poloxamer 188, and dispersed in sodium hyaluronate-formed hydrogel to obtain CHR-Lip-Gel. The resulting CHR-Lip in the hydrogel had a complete vesicle structure, with a particle size of 143.50 ± 8.20 nm. CHR-Lip-Gel significantly (p