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Head-to-Head Comparison of Response Rates to the Two mRNA SARS-CοV-2 Vaccines in a Large Cohort of Solid Organ Transplant (SOT) Recipients

Authors :
Smaragdi Marinaki
Dimitrios Degiannis
Sotirios Roussos
Efstathios Xagas
Paraskevi Tsoutsoura
Stamatis Adamopoulos
Vana Sypsa
Antigoni Chaidaroglou
Ioanna D. Pavlopoulou
Angelos Hatzakis
Ioannis N. Boletis
Source :
Vaccines, Vol 10, Iss 2, p 190 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Due to their higher risk of developing life-threatening COVID-19 disease, solid organ transplant (SOT) recipients have been prioritized in the vaccination programs of many countries. However, there is increasing evidence of reduced immunogenicity to SARS-CοV-2 vaccination. The present study investigated humoral response, safety, and effectiveness after the two mRNA vaccines in 455 SOT recipients. Overall, the antibody response rate was low, at 39.6%. Higher immunogenicity was detected among individuals vaccinated with the mRNA1273 compared to those with the BNT162b2 vaccine (47% vs. 36%, respectively, p = 0.025) as well as higher median antibody levels of 31 (7, 372) (AU/mL) vs. 11 (7, 215) AU/mL, respectively. Among the covariates assessed, vaccination with the BNT162b2 vaccine, antimetabolite- and steroid-containing immunosuppression, female gender, the type of transplanted organ and older age were factors that negatively influenced immune response. Only mild adverse effects were observed. Our findings confirm poor immunogenicity after vaccination, implicating a reevaluation of vaccination policy in SOT recipients.

Details

Language :
English
ISSN :
2076393X
Volume :
10
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.8a22786d359249b094930a4d87738413
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines10020190