Back to Search
Start Over
Comparison of histological and computed tomographic measurements of pig lung bronchi
- Source :
- ERJ Open Research, Vol 6, Iss 4 (2020)
- Publication Year :
- 2020
- Publisher :
- European Respiratory Society, 2020.
-
Abstract
- Aim Light microscopy is used as template in the evaluation and further development of medical imaging methods. Tissue shrinkage caused by histological processing is known to influence lung tissue dimensions. In diagnosis of COPD, computed tomography (CT) is widely used for automated airway measurement. The aim of this study was to compare histological and computed tomographic measurements of pig lung bronchi. Methods Airway measurements of pig lungs were performed after freezing under controlled inflation pressure in a liquid nitrogen bath. The wall thickness of seven bronchi was measured via Micro-CT and CT using the integral-based method (IBM) and the full-width-at-half-maximum method (FWHM) automatically and histologically on frozen and paraffin sections. Statistical analysis was performed using the Wilcoxon test, Pearson's correlation coefficient with a significance level at p
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 23120541
- Volume :
- 6
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- ERJ Open Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8adffb65413145abae4b40e7ac0faf10
- Document Type :
- article
- Full Text :
- https://doi.org/10.1183/23120541.00500-2020