The clinical, economic, and patient‐centric burden of insomnia symptom severity in adults with major depressive disorder in the United States

Abstract Introduction Insomnia is prevalent in adults with major depressive disorder (MDD) and is a key diagnostic criterion of MDD; however, little is understood about the burden of insomnia symptom severity in MDD. We evaluated the relationship between insomnia symptom severity and the clinical, economic, and patient‐centric burden among community‐dwelling individuals with MDD. Methods Respondents with diagnosed depression who reported insomnia symptoms in the past 12 months (N = 4402) were identified from the 2019 United States National Health and Wellness Survey. Multivariable analyses assessed the association of Insomnia Severity Index (ISI) with health‐related outcomes while controlling for sociodemographic and health characteristics. Further analyses also controlled for depression severity (9‐item Patient Health Questionnaire). Results Mean ISI score was 14.3 ± 5.6. Higher ISI was associated with greater depression severity (r = .51, p