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Understanding the mechanism of Pd-catalyzed allylic substitution of the cyclic difluorinated carbonates
- Source :
- Beilstein Journal of Organic Chemistry, Vol 4, Iss 1, p 18 (2008)
- Publication Year :
- 2008
- Publisher :
- Beilstein-Institut, 2008.
-
Abstract
- We present a mechanistic investigation of Pd-catalyzed allylic substitution of cyclic gem-difluorinated carbonates 1 and 4, previously employed in the synthesis of 3',3'-difluoro-2'-hydroxymethyl-4',5'-unsaturated carbocyclic nucleosides in 17 steps. The substitution features a reversal of regioselectivity caused by fluorine.
- Subjects :
- Science
Organic chemistry
QD241-441
Subjects
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 4
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Beilstein Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8af97623a56147f4aa9d2990d6c0ea20
- Document Type :
- article
- Full Text :
- https://doi.org/10.3762/bjoc.4.18