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Bacterial encapsulins as orthogonal compartments for mammalian cell engineering

Authors :
Felix Sigmund
Christoph Massner
Philipp Erdmann
Anja Stelzl
Hannes Rolbieski
Mitul Desai
Sarah Bricault
Tobias P. Wörner
Joost Snijder
Arie Geerlof
Helmut Fuchs
Martin Hrabĕ de Angelis
Albert J. R. Heck
Alan Jasanoff
Vasilis Ntziachristos
Jürgen Plitzko
Gil G. Westmeyer
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Artificial compartments have been expressed in prokaryotes and yeast, but similar capabilities have been missing for mammalian cell engineering. Here the authors use bacterial encapsulins to engineer genetically controlled multifunctional orthogonal compartments in mammalian cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8b0b99fc471b4375adafc9f1ec3ae965
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04227-3