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Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- COBRA1 is a BRCA1-binding protein and, as part of the negative elongation factor, regulates RNA polymerase II pausing and transcription elongation. Here, the authors show that tissue-specific deletion of mouse Cobra1 inhibits postnatal mammary gland development and that the mammary defects can be rescued by additional deletion of Brca1in a DNA repair-independent manner.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8b1af6dbaf6435f9056729025693328
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms10913