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Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer

Authors :
Bhasker Dharavath
Ashwin Butle
Ankita Pal
Sanket Desai
Pawan Upadhyay
Aishwarya Rane
Risha Khandelwal
Sujith Manavalan
Rahul Thorat
Kavita Sonawane
Richa Vaish
Poonam Gera
Munita Bal
Anil K. D’Cruz
Sudhir Nair
Amit Dutt
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

MMP10, which is upregulated in 86% of primary tongue tumors with lymph node metastases, is negatively regulated by miR-944 and promotes nodal metastasis in an orthotopic tongue cancer mouse model through the AXL signaling pathway.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.8b679bba12d74b7cbe272b8156ba0657
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04437-6