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Prophylactic cranial irradiation for extensive-stage small cell lung cancer: Analysis based on active brain MRI surveillance
- Source :
- Clinical and Translational Radiation Oncology, Vol 25, Iss , Pp 16-21 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background and purpose: The value of prophylactic cranial irradiation (PCI) for extensive-stage small-cell lung cancer (ES-SCLC) has recently been challenged. This study was conducted to evaluate the role of PCI for ES-SCLC under active brain magnetic resonance imaging (MRI) surveillance. Materials and methods: Patients with ES-SCLC who showed any responses after first-line chemotherapy and no initial brain metastasis (BM) were retrospectively included. Active brain MRI surveillance was performed for all patients. Progression-free survival (PFS) and overall survival (OS) were compared between PCI and non-PCI patients. The time-related hazard of BM was evaluated in non-PCI patients. Results: One hundred and eighteen consecutive patients were included in the study. The median follow-up time was 26.5 months (3–72 months). The median PFS and OS were better in the PCI cohort than in the non-PCI group. Multivariate analyses revealed first-line chemotherapy cycles (> 4 vs. ≤ 4 cycles, HR: 0.29; 95% CI: 0.15–0.55, P
Details
- Language :
- English
- ISSN :
- 24056308
- Volume :
- 25
- Issue :
- 16-21
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Translational Radiation Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8b6d428aee5404792b2608ab26dd6c0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ctro.2020.09.005