Pathogenic factors and clinical characteristics of 104 cirrhosis cases in Shangri-La area, Yunnan

Objective: To analyze the main etiology and clinical features of cirrhosis in Shangri-La area of Yunnan and provide clinical data for prevention and control in such area. Methods: A total of 104 patients with cirrhosis admitted to the People’s Hospital of Diqing Tibetan Autonomous Prefecture from January 2019 to June 2021 were enrolled, and the etiological composition and main clinical characteristics of patients with cirrhosis in Shangri-La were analyzed retrospectively. Results: Patients with cirrhosis ranged from 33 to 86 years old, with an average age of (59.5±11.3) years old. The male to female ratio was 9 to 4. It revealed that 62.5% patients were Tibetans, 17.31% were Han Nationality, 15.38% were Yi Nationality. For Child-Pugh grading, 38 cases (37%) were with Child-PughA, 56 cases(54%) were with Child-pugh grade B, and 10 cases (9%) cases were with Child-pugh grade C. The main reason for the visit was abdominal distension. For etiological composition, alcoholic cirrhosis accounted for 38%. Hepatitis B cirrhosis accounted for 48%. Hepatitis C cirrhosis accounted for 1%. Mixed sclerosis accounted for 13%. The age of onset of cirrhosis caused by all causes is younger than those in other parts of the country, especially the age of onset of alcoholic cirrhosis is younger and the prognosis remission rate after standard treatment was only 1%. Conclusions: Viral hepatitis is still the main cause of cirrhosis in this region, followed by alcoholic liver disease and mixed cirrhosis. Attention should be paid to the harm of alcohol to human body education in this region, and strengthen the prevention and treatment of viral hepatitis.