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Treatment response in primary biliary cholangitis: The role of autoimmune hepatitis features
- Source :
- Annals of Hepatology, Vol 18, Iss 3, Pp 488-493 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Introduction and aim: Primary biliary cholangitis is a rare disease with scarce epidemiological data in Southern Europe. The authors aimed to evaluate treatment response in a cohort of patients. Materials and methods: This retrospective observational single-centre study included patients with diagnostic criteria of primary biliary cholangitis. Data on disease presentation, laboratory results, treatment and clinical endpoints were collected and analyzed. Results: Fifty-three patients were included, 89% women, with mean age of 62 ± 15 years at diagnosis. The majority was asymptomatic (49%), tested positive for antimitochondrial antibodies (96%) and had increased alkaline phosphatase (median = 214 U/L). 75% of the patients had liver histology and the majority were in Ludwig's stage I (42%). Autoimmune hepatitis (AIH) features were found in seven patients (13%). All were treated with ursodeoxycholic acid (UDCA) and 56% achieved biochemical response at one year; patients with AIH features exhibited steeper decreases in alkaline phosphatase (p = 0.007) and reached the endpoint of 40% decrease in alkaline phosphatase more frequently (p = 0.017). Conclusion: In conclusion a significant proportion of patients failed to achieve an adequate response to UDCA treatment. The response rate of patients with AIH features was better, which could be related to a different phenotype or to the potential impact of immunosuppressive agents.
Details
- Language :
- English
- ISSN :
- 16652681
- Volume :
- 18
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Annals of Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8bf04f5d41d41c4a0adf2ec6df4fb01
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.aohep.2018.11.006