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Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury

Authors :
Sofia Meyer zu Reckendorf
Christine Brand
Maria T. Pedro
Jutta Hegler
Corinna S. Schilling
Raissa Lerner
Laura Bindila
Gregor Antoniadis
Bernd Knöll
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The regeneration dynamics following peripheral nerve injury differs among species. Here, the authors compared transcriptomic and lipid metabolism changes in murine and human Schwann cells in vivo and ex vivo sural nerves, underlying their switch from myelinating to repair state following injury.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8c2c6448c4ef49c4819a929191ec28cb
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15915-4