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Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity

Authors :
Marwa H. Abdallah
Hanaa A. Elghamry
Nasrin E. Khalifa
Weam M. A. Khojali
El-Sayed Khafagy
Amr S. Abu Lila
Hemat El-Sayed El-Horany
Shaimaa El-Housiny
Source :
Gels, Vol 8, Iss 11, p 737 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with sesame oil. Particle size, viscosity, in vitro release, and ex vivo drug penetration experiments were performed on the produced formulations (ginger extract loaded gel, ginger extract loaded emulgel, ginger extract niosomal gel, and ginger extract niosomal emulgel). Carrageenan-induced edema in rat hind paw was employed to estimate the in vivo anti-inflammatory activity. The generated ginger extract formulations showed good viscosity and particle size. The in vitro release of ginger extract from niosomal formulation surpassed other formulations. In addition, the niosomal emulgel formulation showed improved transdermal flux and increased drug permeability through rabbit skin compared to other preparations. Most importantly, carrageenan-induced rat hind paw edema test confirmed the potential anti-inflammatory efficacy of ginger extract niosomal emulgel, compared to other formulations, as manifested by a significant decrease in paw edema with a superior edema inhibition potency. Overall, our findings suggest that incorporating a niosomal formulation within sesame oil-based emulgel might represent a plausible strategy for effective transdermal delivery of anti-inflammatory drugs like ginger extract.

Details

Language :
English
ISSN :
23102861
Volume :
8
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Gels
Publication Type :
Academic Journal
Accession number :
edsdoj.8c795682be9e4b2f8a0814c44c56a8e1
Document Type :
article
Full Text :
https://doi.org/10.3390/gels8110737