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Overview of Studies in Animal Models of Schizophrenia
- Source :
- Shiyan dongwu yu bijiao yixue, Vol 43, Iss 2, Pp 145-155 (2023)
- Publication Year :
- 2023
- Publisher :
- Editorial Office of Laboratory Animal and Comparative Medicine, 2023.
-
Abstract
- Schizophrenia (SCZ) is a highly destructive and complex psychiatric disorder illness, accompanied by a variety of positive and negative symptoms along with cognitive impairment, which brings a heavy social burden. Elucidation of the pathogenesis and therapeutic development is challenging because the complex interplay between genetic risk factors and environmental factors in essential neurodevelopmental processes. Therefore, preparing appropriate animal models can help people better understanding the neurobiological basis of SCZ and provide theoretical basis for finding new treatments. In order to provide reference for the application and improvement of SCZ animal models, this commentary reviewed several main modeling methods for animal models of SCZ, including neurodevelopmental models, drug-induced animal models, and genetic models, and the behavioral evaluation, histological analysis and possible molecular mechanisms of SCZ animal models were also outlined.
- Subjects :
- schizophrenia
animal models
behavior analysis
dopamine
γ-aminobutyric acid
Medicine
Subjects
Details
- Language :
- Chinese
- ISSN :
- 16745817
- Volume :
- 43
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Shiyan dongwu yu bijiao yixue
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8cb41977e42548db914d50870953cd26
- Document Type :
- article
- Full Text :
- https://doi.org/10.12300/j.issn.1674-5817.2022.174