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The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia

Authors :
Norikazu Ueki
Satoru Takeda
Daisuke Koya
Keizo Kanasaki
Source :
International Journal of Endocrinology, Vol 2015 (2015)
Publication Year :
2015
Publisher :
Hindawi Limited, 2015.

Abstract

Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5–8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called “a disease of theories.” The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hypertension in preeclampsia and its association with the renin-angiotensin system. In addition, we propose potential alternative strategies to target the renin-angiotensin system, which is enhanced during pregnancy.

Details

Language :
English
ISSN :
16878337 and 16878345
Volume :
2015
Database :
Directory of Open Access Journals
Journal :
International Journal of Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.8cc5023e3fd0489ca6c5da7b3339406b
Document Type :
article
Full Text :
https://doi.org/10.1155/2015/572713