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Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Authors :
Xu Zhang
Muath Bishawi
Ge Zhang
Varun Prasad
Ellen Salmon
Jason J. Breithaupt
Qiao Zhang
George A. Truskey
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several drugs.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8d57cac5f23b4a1ca7ed71c83c025052
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-19197-8