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A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- The proteasome, an essential molecular machine, is a threonine protease, but the evolution and the components of its proteolytic centre are unclear. Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8d736013f95044c8b26f6406a2319c6e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms10900