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Chiral microenvironment-responsive mesoporous silica nanoparticles for delivering indometacin with chiral recognition function

Authors :
Kaijun Gou
Xianmou Guo
Yuxin Wang
Yumei Wang
Zhentao Sang
Shuangshuang Ma
Yingyu Guo
Linlin Xie
Sanming Li
Heran Li
Source :
Materials & Design, Vol 214, Iss , Pp 110359- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

The purpose of this study was to investigate the potential chiral recognition functions induced by two kinds of novel chiral microenvironment-responsive mesoporous silica nanoparticles (CMR-L-MSN and CMR-D-MSN) for the oral delivery of the poorly water-soluble achiral drug indomethacin (IMC). The as-synthesized CMR-L-MSN and CMR-D-MSN with molecular chirality and high specific surface area (SBET: 1141 and 1075 m2/g, respectively) were successfully prepared through grafting chiral molecular functional groups. The characterization results showed that CMR-L-MSN and CMR-D-MSN were spherical nanoparticles with opposite chiral features and clearly visible pore channels. Meanwhile, they exhibited good biosafety and degradability. In vitro drug release study indicated that both CMR-L-MSN and CMR-D-MSN significantly improved IMC dissolution compared with naked-MSN (N-MSN) (p

Details

Language :
English
ISSN :
02641275
Volume :
214
Issue :
110359-
Database :
Directory of Open Access Journals
Journal :
Materials & Design
Publication Type :
Academic Journal
Accession number :
edsdoj.8dd4785c867449d93ee17b838a315a6
Document Type :
article
Full Text :
https://doi.org/10.1016/j.matdes.2021.110359