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Chiral microenvironment-responsive mesoporous silica nanoparticles for delivering indometacin with chiral recognition function
- Source :
- Materials & Design, Vol 214, Iss , Pp 110359- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- The purpose of this study was to investigate the potential chiral recognition functions induced by two kinds of novel chiral microenvironment-responsive mesoporous silica nanoparticles (CMR-L-MSN and CMR-D-MSN) for the oral delivery of the poorly water-soluble achiral drug indomethacin (IMC). The as-synthesized CMR-L-MSN and CMR-D-MSN with molecular chirality and high specific surface area (SBET: 1141 and 1075 m2/g, respectively) were successfully prepared through grafting chiral molecular functional groups. The characterization results showed that CMR-L-MSN and CMR-D-MSN were spherical nanoparticles with opposite chiral features and clearly visible pore channels. Meanwhile, they exhibited good biosafety and degradability. In vitro drug release study indicated that both CMR-L-MSN and CMR-D-MSN significantly improved IMC dissolution compared with naked-MSN (N-MSN) (p
Details
- Language :
- English
- ISSN :
- 02641275
- Volume :
- 214
- Issue :
- 110359-
- Database :
- Directory of Open Access Journals
- Journal :
- Materials & Design
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8dd4785c867449d93ee17b838a315a6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.matdes.2021.110359