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CON: GLUCOSE IS THE MOST IMPORTANT TARGET FOR CARDIOVASCULAR PREVENTION IN DIABETES

CON: GLUCOSE IS THE MOST IMPORTANT TARGET FOR CARDIOVASCULAR PREVENTION IN DIABETES

Authors :
Francesco Giorgino
Source :
Artery Research, Vol 20 (2017)
Publication Year :
2017
Publisher :
BMC, 2017.

Abstract

The overall impact of glucose-lowering on vascular complications and major clinical outcomes, including mortality, in type 2 diabetes is still an open issue. While intensive glucose control has undoubted benefit for microvascular endpoints, the relationship between glucose-lowering approaches and reduced incidence and/or progression of macrovascular complications is less clear. This presentation will discuss the effect of glucose-lowering per se as well as the effects of specific glucose-lowering therapies on vascular outcomes in type 2 diabetes. Recent analyses from large cardiovascular outcome studies (ACCORD, ADVANCE, VADT) provide new information on factors that modulate the impact of intensive glucose-lowering on outcomes, helping to identify the specific clinical characteristics of the patients receiving the intervention that would show better response. Several studies on cardiovascular outcomes with diabetes drugs are now available, and they highlight cardiovascular benefits from using specific medications, as for the SGLT-2 blockers and some GLP-1 receptor agonists.

Details

Language :
English
ISSN :
18764401
Volume :
20
Database :
Directory of Open Access Journals
Journal :
Artery Research
Publication Type :
Academic Journal
Accession number :
edsdoj.8e3ac2bbe00c40c49b53ca6adf6220c0
Document Type :
article
Full Text :
https://doi.org/10.1016/j.artres.2017.10.012