Efficiency of Аdaptol in Comprehensive Treatment of Patients with Thyrotoxicosis Syndrome

Objective — to study Adaptol efficiency in patients with diffuse toxic goiter (DTG) of varying severity with deviations in the emotional sphere without expressed psychoorganic disorders, as well as impact of the drug on the efficiency of main thyrostatic therapy that allows to expand the range of indications for the use of the drug in the practice of endocrinologists. Materials and methods. We observed 25 patients with thyrotoxicosis in a state of drug subcompensation (17 — with the overt one, which developed as a result of DTG, and 8 — with subclinical one), who received Adaptol in combination treatment for two months (group I). Another 20 patients with similar pathology formed the control group (group II). Patients in the control group did not differ statistically significantly by the age, sex, duration and severity of DTG from those of the main group. Results. The analysis of the findings indicates that in the first (main) group of patients with DTG (with additional administration of Adaptol), there is a more significant effect of treatment compared with patients in the control group. Additional use of Adaptol helped to reduce the daily dose of thyrostatics in patients with DTG that reduces the risk of complications of the therapy. If the average daily dose of thiamazole/carbimazole at the beginning of treatment in the examined groups of patients did not differ, then after 2 months of treatment, the mean dose of thyrostatics in the first group was 24.3 ± 2.1 mg, in the control group — 31.8 ± 2.4 mg (p < 0.05). During therapy with Adaptol, there was a decrease (p < 0.05) in the content of malondialdehyde, as well as increase in the activity of antioxidant defense enzymes: superoxide dismutase (p < 0.05) and glutathione peroxidase (p < 0.05). Conclusions. After 2 months of Adaptol therapy, according to the Hamilton scale, patients of the main group hadn’t anxiety states (5.6 ± 1.2 points; p < 0.05), whereas in the control group, there were symptoms of anxiety (14.8 ± 2.7 points; p < 0.05). Adaptol has a positive therapeutic effect on both the oxidant and antioxidant systems that manifests by inhibition of lipid peroxidation and activation of compensatory processes. In view of the research, application of Adaptol must take the proper place in the schemes of treatment for DTG and to expand its possibilities in case of both mild and long-term course of the disease.