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Normal Immunostaining Pattern for Aquaporin-5 in the Lesions of Palmoplantar Hyperhidrosis
- Source :
- Case Reports in Dermatology, Vol 5, Iss 1, Pp 61-63 (2013)
- Publication Year :
- 2013
- Publisher :
- Karger Publishers, 2013.
-
Abstract
- Aquaporin-5 (AQP-5) is a water-transporting protein expressed in mammal sweat glands. It has been reported that the expression of AQP-5 is involved in sweating of mice, rats, and horses. However, the physiological function of human AQP-5 is still uncertain. In this report, we examined the expression pattern of AQP-5 in the skin lesions of palmoplantar hyperhidrosis in patients with Nagashima-type palmoplantar hyperkeratosis (PPK). We found that there was no significant difference in AQP-5 expression in the palmoplantar skin of healthy subjects and patients with palmoplantar hyperhidrosis. Our findings suggest that a mechanism other than AQP-5 may be involved in the pathogenesis of hyperhidrosis in PPK.
- Subjects :
- Palmoplantar hyperhidrosis
Aquaporin-5
Dermatology
RL1-803
Subjects
Details
- Language :
- English
- ISSN :
- 16626567
- Volume :
- 5
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Case Reports in Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8f0a154cb6b64547b5f4fa497318d5c2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1159/000349908