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nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8f56e6d3aab84052a130814cd8153048
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-16198-5