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Frequency and genotype distribution of hepatitis C virus infection in patients with diabetes type 2 in Ahvaz, Iran
- Source :
- Iranian Journal of Microbiology, Vol 13, Iss 5 (2021)
- Publication Year :
- 2021
- Publisher :
- Tehran University of Medical Sciences, 2021.
-
Abstract
- Background and Objectives: Diabetes is recognized as a great concern and a public health problem worldwide. Several factors including environmental and genetic factors have been involved. Recently, infectious agents such as hepatitis C virus (HCV) have been reported to be associated with diabetes. Thus, this study was conducted to determine the frequency of HCV infection among patients with diabetes type 2 in Ahvaz city, Iran. Materials and Methods: A case-control study design was conducted at Ahvaz Jundishapur University of Medical Sciences. A total of 600 study subjects were included in this research. All the patient sera were tested for Anti- HCV antibody, HBsAg, and HIV antibody. The sera of positive Anti-HCV antibody, were assayed for 5'- UTR and core regions of the HCV genome by Nested RT-PCR. Finally, the HCV genotyping was determined by sequencing. Results: The prevalence of HCV in type 2 diabetes and nondiabetic controls was 2% and 0.33%, respectively. The distribution of HCV genotypes among the HCV-positive patients were 3a (1.66%) and 1a (0.33%). Conclusion: To control and improve the treatment, the screening of HCV infection with anti-HCV antibody was followed by molecular techniques such as PCR and HCV genotyping which should be implemented for all patients with diabetes type 2.
- Subjects :
- Diabetes mellitus type 2
HCV
Prevalence
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 20083289 and 20084447
- Volume :
- 13
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Iranian Journal of Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9003b440a05e4ba9ace571aecd6022b5
- Document Type :
- article
- Full Text :
- https://doi.org/10.18502/ijm.v13i5.7437