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Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis

Authors :
Tommaso Cai
Umberto Anceschi
Irene Tamanini
Serena Migno
Michele Rizzo
Giovanni Liguori
Alejandro Garcia-Larrosa
Alessandro Palmieri
Paolo Verze
Vincenzo Mirone
Truls E. Bjerklund Johansen
Source :
Antibiotics, Vol 11, Iss 1, p 14 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Background: In the era of antibiotic resistance, an antibiotic-sparing approach presents an interesting alternative treatment of uncomplicated cystitis in women. Our aim is to perform a systematic review and meta-analysis to compare the effectiveness and safety profile of a medical device containing xyloglucan, hibiscus and propolis (XHP) in women with uncomplicated cystitis. Methods: Relevant databases were searched using methods recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The primary endpoint was clinical or microbiological success, defined as the complete (cure) and/or non-complete (improvement) resolution of symptoms at the end of treatment, or microbiological resolutions. Results: After screening 21 articles, three studies were included, recruiting a total of 178 patients. All three studies used placebo as comparator. A statistically significant difference was found in terms of clinical or microbiological resolution between the medical device and the comparator (3 RCTs, 178 patients, OR: 0.13; 95% CI: 0.05–0.33; p < 0.0001). No clinically significant adverse effects have been reported. Conclusion: A medical device containing xyloglucan, hibiscus and propolis is superior to comparator regimens in terms of clinical effectiveness in adult women with microbiologically confirmed or clinical suspicion of uncomplicated cystitis and is associated with a high patient compliance.

Details

Language :
English
ISSN :
20796382
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Antibiotics
Publication Type :
Academic Journal
Accession number :
edsdoj.903f86f6be004c97a6d9bafa799e7108
Document Type :
article
Full Text :
https://doi.org/10.3390/antibiotics11010014