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Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series

Authors :
Hwa Jin Lee
Gwang Ha Kim
Dong Chan Joo
Moon Won Lee
Bong Eun Lee
Kyungbin Kim
Source :
The Korean Journal of Gastroenterology, Vol 81, Iss 6, Pp 259-264 (2023)
Publication Year :
2023
Publisher :
Jin Publishing & Printing Co., 2023.

Abstract

The fundic gland type (GA-FG) of gastric adenocarcinoma is a rare variant of gastric cancer recently included in the 5th edition of the World Health Organization’s classification of digestive system tumors. Five patients with GA-FG underwent an endoscopic resection at our institution. None of the patients had a Helicobacter pylori infection. Four lesions were located in the upper third of the stomach, and one was in the lower third. Three lesions had a IIa shape, while two resembled a subepithelial tumor. An endoscopic submucosal dissection was performed in four patients and endoscopic mucosal resection in one. Tumor cells were composed of well-differentiated columnar cells mimicking fundic gland cells, and the median tumor size was 10 mm. Three lesions exhibited submucosal invasion. No lymphatic or venous invasion was observed. Tumor cells were positive for MUC6 in all five cases; one case was focally positive for MUC5AC. No recurrence was observed during a median follow-up period of 13 months. An endoscopic resection can be a safe treatment modality for GA-FG, considering its small size and low risk of recurrence or metastasis.

Details

Language :
English, Korean
ISSN :
15989992 and 22336869
Volume :
81
Issue :
6
Database :
Directory of Open Access Journals
Journal :
The Korean Journal of Gastroenterology
Publication Type :
Academic Journal
Accession number :
edsdoj.90b845efb83343c7824962679464e440
Document Type :
article
Full Text :
https://doi.org/10.4166/kjg.2023.019