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Global Distribution and Molecular Evolution of Bat Coronaviruses

Authors :
Mohamed El Sayes
Rebecca Badra
Mohamed A. Ali
Rabeh El-Shesheny
Ghazi Kayali
Source :
Zoonotic Diseases, Vol 4, Iss 2, Pp 146-161 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Bat coronaviruses cause a wide range of illnesses in humans and animals. Bats are known to harbor a wide diversity of Alphacoronaviruses and Betacoronaviruses. Betacoronaviruses have been linked to Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and other diseases such as gastroenteritis, bronchiolitis, and pneumonia. In the last 20 years, three betacoronaviruses emerged and caused widespread outbreaks in humans, including two deadly betacoronavirus epidemics, SARS-CoV, with mortality rate of 10%, and MERS-CoV, with mortality rate of 34.7%, and SARS-CoV-2, which caused the COVID-19 pandemic, with mortality rate of 3.4%. Studies have shown that bats are the main natural reservoirs for these viruses or their ancestral viruses. Observed variations in bat coronavirus genomes indicate that these viruses may have a potential to transmit to other hosts in close contact with humans and subsequently transmit to humans. As of today, there are no reported cases of direct coronavirus transmission from bats to humans. One reason for this might be that intermediate hosts are required for the transmission of bat coronaviruses to humans. Further studies are needed to map the amino acids and genomic regions responsible for the interactions between the spike of coronavirus and its receptors.

Details

Language :
English
ISSN :
28130227
Volume :
4
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Zoonotic Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.91058b64a56340a8987d1fd190075bff
Document Type :
article
Full Text :
https://doi.org/10.3390/zoonoticdis4020014