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Prospective Study in Children with Complicated Urinary Tract Infection Treated with Autologous Bacterial Lysates

Authors :
Ulises Hernández-Chiñas
María E. Chávez-Berrocal
Ricardo E. Ahumada-Cota
Armando Navarro-Ocaña
Luz M. Rocha-Ramírez
Yolanda Pérez-del Mazo
Maribel Alvarado-Cabello
Gabriel Pérez-Soto
Luis A. León-Alamilla
Salvador E. Acevedo-Monroy
Diego Esquiliano
Atlántida M. Raya-Rivera
Carlos A. Eslava
Source :
Microorganisms, Vol 9, Iss 9, p 1811 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Antimicrobial bacteria resistance is an important problem in children with recurrent urinary tract infections (rUTI), thus it is crucial to search for alternative therapies. Autologous bacterial lysates (ABL) may be a potential treatment for rUTI. Twenty-seven children with rUTI were evaluated for one year, urine and stool cultures were performed, 10 colonies of each culture were selected and those identified as Escherichia coli were characterized by serology. For patients who presented ≥105 UFC/mL, an ABL was manufactured and administered orally (1 mL/day) for a month. Twelve children were monitored for ≥1-year, 218 urine and 11 stool samples were analyzed. E. coli (80.5%) was the main bacteria isolated from urine and feces (72%). E. coli of classical urinary serotypes (UPEC), O25:H4, O75:HNM, and O9:HNM were identified in patients with persistent urinary infection (pUTI). In 54% of patients treated with ABL, the absence of bacteria was observed in urine samples after 3 months of treatment, 42% of these remained without UTI between 10–12 months. It was observed that the use of ABL controlled the infection for almost 1 year in more than 60% of the children. We consider it necessary to develop a polyvalent immunogen for the treatment and control of rUTI.

Details

Language :
English
ISSN :
20762607
Volume :
9
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.91866b3d09614e1a89b0d53d308c59a8
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms9091811