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Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis

Authors :
Songul Ozyurt
Neslihan Ozcelik
Bilge Yilmaz Kara
Medeni Arpa
Yavuz Metin
Ozcan Erel
Salim Neselioglu
Source :
Canadian Respiratory Journal, Vol 2022 (2022)
Publication Year :
2022
Publisher :
Hindawi Limited, 2022.

Abstract

Purpose. Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls. Materials and Methods. Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (−SH); TT: total thiol (−SH + SS); SS: disulfide (−SS); SS-SH: disulfide/native thiol index; SS-TT: disulphide/total thiol index; SH-TT: native thiol/total thiol index), and ischemia-modified albumin (IMA) levels were examined in the stable bronchiectasis group and the control group. Thiol-disulfide homeostasis was evaluated using a novel and automated assay. Findings and Result. Blood native thiol levels in patients with stable bronchiectasis were found to be significantly higher compared with healthy controls. A positive correlation between the total airway disease score and IMA levels was present. Our findings revealed that native thiol levels, which constitute a part of the antioxidant defense system, are increased in patients with stable bronchiectasis.

Details

Language :
English
ISSN :
19167245
Volume :
2022
Database :
Directory of Open Access Journals
Journal :
Canadian Respiratory Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.920fa9c163424f749a34c155f713207b
Document Type :
article
Full Text :
https://doi.org/10.1155/2022/8340450