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Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

Authors :
Zelong Ma
Faxiao Zhou
Hua Jin
Xiaoming Wu
Source :
Cells, Vol 13, Iss 12, p 1027 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple mechanisms, while the STAT3 pathway also regulates the expression of CXCL12. This review offers a thorough and systematic analysis of the reciprocal regulatory mechanisms between the CXCL12/CXCR4/ACKR3 signaling axis and the STAT3 signaling pathway in the context of diseases, particularly tumors. It explores the potential clinical applications in tumor treatment, highlighting possible therapeutic targets and novel strategies for targeted tumor therapy.

Details

Language :
English
ISSN :
20734409
Volume :
13
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.9280ec703be04780916bf7ee3d84a46e
Document Type :
article
Full Text :
https://doi.org/10.3390/cells13121027