Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Authors :: Gwen Lomberk
Yuna Blum
Rémy Nicolle
Asha Nair
Krutika Satish Gaonkar
Laetitia Marisa
Angela Mathison
Zhifu Sun
Huihuang Yan
Nabila Elarouci
Lucile Armenoult
Mira Ayadi
Tamas Ordog
Jeong-Heon Lee
Gavin Oliver
Eric Klee
Vincent Moutardier
Odile Gayet
Benjamin Bian
Pauline Duconseil
Marine Gilabert
Martin Bigonnet
Stephane Garcia
Olivier Turrini
Jean-Robert Delpero
Marc Giovannini
Philippe Grandval
Mohamed Gasmi
Veronique Secq
Aurélien De Reyniès
Nelson Dusetti
Juan Iovanna
Raul Urrutia
Source :: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Publication Year :: 2018
Publisher :: Nature Portfolio, 2018.
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.

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