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GATA transcription factor required for immunity to bacterial and fungal pathogens.
- Source :
- PLoS ONE, Vol 1, p e77 (2006)
- Publication Year :
- 2006
- Publisher :
- Public Library of Science (PLoS), 2006.
-
Abstract
- In the past decade, Caenorhabditis elegans has been used to dissect several genetic pathways involved in immunity; however, little is known about transcription factors that regulate the expression of immune effectors. C. elegans does not appear to have a functional homolog of the key immune transcription factor NF-kappaB. Here we show that that the intestinal GATA transcription factor ELT-2 is required for both immunity to Salmonella enterica and expression of a C-type lectin gene, clec-67, which is expressed in the intestinal cells and is a good marker of S. enterica infection. We also found that ELT-2 is required for immunity to Pseudomonas aeruginosa, Enterococcus faecalis, and Cryptococcus neoformans. Lack of immune inhibition by DAF-2, which negatively regulates the FOXO transcription factor DAF-16, rescues the hypersusceptibility to pathogens phenotype of elt-2(RNAi) animals. Our results indicate that ELT-2 is part of a multi-pathogen defense pathway that regulates innate immunity independently of the DAF-2/DAF-16 signaling pathway.
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.934816f978a94b6e9b352641cf177ab3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pone.0000077