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An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

Authors :
Jia-Bin Wang
Ping Li
Xiao-Long Liu
Qiao-Ling Zheng
Yu-Bin Ma
Ya-Jun Zhao
Jian-Wei Xie
Jian-Xian Lin
Jun Lu
Qi-Yue Chen
Long-Long Cao
Mi Lin
Li-Chao Liu
Ning-Zi Lian
Ying-Hong Yang
Chang-Ming Huang
Chao-Hui Zheng
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Expression patterns of immune checkpoints in patients with gastric cancer remain poorly characterized. Here the authors propose an immune scoring system based on the expression of six immunosuppressive ligands to improve the prognostic accuracy in gastric cancer patients and drive the selection of candidates for adjuvant chemotherapy.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.935dcdd3fb754d679c625e6ae83c17b9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-20260-7