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Molecular layer interneurons in the cerebellum encode for valence in associative learning

Authors :
Ming Ma
Gregory L. Futia
Fabio M. Simoes de Souza
Baris N. Ozbay
Isabel Llano
Emily A. Gibson
Diego Restrepo
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

This study shows that cerebellar molecular layer interneurons (MLIs) develop responses encoding for identity of the stimulus in an associative learning task. Chemogenetic inhibition of MLIs decreased the ability of mice to discriminate stimuli suggesting that MLIs encode for stimulus valence.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.939dd0379a7491e9b71c703b9d39a49
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-18034-2