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Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level

Authors :
Helen R. Clark
Connor McKenney
Nathan M. Livingston
Ariel Gershman
Seema Sajjan
Isaac S. Chan
Andrew J. Ewald
Winston Timp
Bin Wu
Abhyudai Singh
Sergi Regot
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Fine tuning the immune response in line with the degree of threat is central to recognition of a pathogen versus commensal bacteria. Here the authors implicate a digital all-or-nothing cell response in control of the tissue level immune response.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.941a781c5064d999cddc94eed6d7777
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22070-x