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The role of the gut microbiota in neurodegenerative diseases targeting metabolism

Authors :
Yufeng Fu
Zhongya Gu
Huan Cao
Chengchao Zuo
Yaqi Huang
Yu Song
Yongsheng Jiang
Furong Wang
Source :
Frontiers in Neuroscience, Vol 18 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

In recent years, the incidence of neurodegenerative diseases (NDs) has gradually increased over the past decades due to the rapid aging of the global population. Traditional research has had difficulty explaining the relationship between its etiology and unhealthy lifestyle and diets. Emerging evidence had proved that the pathogenesis of neurodegenerative diseases may be related to changes of the gut microbiota’s composition. Metabolism of gut microbiota has insidious and far-reaching effects on neurodegenerative diseases and provides new directions for disease intervention. Here, we delineated the basic relationship between gut microbiota and neurodegenerative diseases, highlighting the metabolism of gut microbiota in neurodegenerative diseases and also focusing on treatments for NDs based on gut microbiota. Our review may provide novel insights for neurodegeneration and approach a broadly applicable basis for the clinical therapies for neurodegenerative diseases.

Details

Language :
English
ISSN :
1662453X
Volume :
18
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.9424999865f948a0a28a8f63d73189c4
Document Type :
article
Full Text :
https://doi.org/10.3389/fnins.2024.1432659