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Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside
- Source :
- Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100045- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulations. Thus, we compared the anti-SARS-CoV-2 activity of remdesivir and GS-441524 in Vero E6, Vero CCL-81, Calu-3, Caco-2 cells, and anti-HCoV-OC43 activity in Huh-7 cells. We also compared the cellular pharmacology of these two compounds in Vero E6, Vero CCL-81, Calu-3, Caco-2, Huh-7, 293T, BHK-21, 3T3 and human airway epithelial (HAE) cells. Overall, remdesivir exhibited greater potency and superior intracellular metabolism than GS-441524 except in Vero E6 and Vero CCL-81 cells.
Details
- Language :
- English
- ISSN :
- 25902571
- Volume :
- 2
- Issue :
- 100045-
- Database :
- Directory of Open Access Journals
- Journal :
- Current Research in Pharmacology and Drug Discovery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.94330ccb3e0445a8d9165b90ad608da
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.crphar.2021.100045