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Microscopic Colitis and Celiac Disease: Sharing More than a Diagnostic Overlap

Authors :
Ana María González-Castro
Fernando Fernández-Bañares
Yamile Zabana
Georgina Farago-Pérez
Jonathan Ortega-Barrionuevo
Elba Expósito
Danila Guagnozzi
Source :
Nutrients, Vol 16, Iss 14, p 2233 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Microscopic colitis (MC) is an emergent group of chronic inflammatory diseases of the colon, and celiac disease (CD) is a chronic gluten-induced immune-mediated enteropathy affecting the small bowel. We performed a narrative review to provide an overview regarding the relationship between both disorders, analyzing the most recent studies published at the epidemiological, clinical and pathophysiological levels. In fact, MC and CD are concomitantly prevalent in approximately 6% of the cases, mainly in the subset of refractory patients. Thus, physicians should screen refractory patients with CD against MC and vice versa. Both disorders share more than a simple epidemiological association, being multifactorial diseases involving innate and adaptive immune responses to known or unknown luminal factors based on a rather common genetic ground. Moreover, autoimmunity is a shared characteristic between the patients with MC and those with CD, with autoimmunity in the latter being quite well-established. Furthermore, CD and MC share some common clinical symptoms and risk factors and overlap with other gastrointestinal diseases, but some differences exist between both disorders. More studies are therefore needed to better understand the complex mechanisms involving the common pathogenetic ground contributing to the CD and MC epidemiological association.

Details

Language :
English
ISSN :
16142233, 20726643, and 94534934
Volume :
16
Issue :
14
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.945349342741481eaeb03e56cb410579
Document Type :
article
Full Text :
https://doi.org/10.3390/nu16142233