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Ozonized vegetable oils and therapeutic properties: A review

Authors :
Nathália R. Almeida
Adilson Beatriz
Ana Camila Micheletti
Eduardo José de Arruda
Source :
Orbital: The Electronic Journal of Chemistry, Vol 4, Iss 4, Pp 313-326 (2013)
Publication Year :
2013
Publisher :
Universidade Federal de Mato Grosso do Sul, 2013.

Abstract

Derived from ozonetherapy, the ozonized oils represent an Ozonized oils represent an interesting pharmaceutical approach to the management of a variety of dermatological pathologies. Ozone reacts with carbon-carbon double bonds of unsaturated fatty acids according to the mechanism described by Criegee, forming ozonides or 1,2,4 trioxolane rings and peroxides as the most important products, responsible for the antimicrobial activity and stimulating tissue repair and regeneration properties. The ozonized vegetable oils can be liquids or semisolids at room temperature and have stability periods that may be adequate for commercial distribuition. Ozonized sunflower oil (Oleozon®), a drug registered nationally and developed in the Ozone Research Center in Cuba has been tested and it was found to have valuable antimicrobial activity against bacteria, fungi and virus. FT-IR and NMR technics are used to confirm the structural changes undergone by oil during the ozonation. For determining the quality of ozonized oils, analytical methods such as peroxide, acidity and iodine values are usually carried out. Products are available for an alternative use of available resources, natural and renewable sources, simple technology, low cost and with extensive biological activity with reduced collateral effects. DOI: http://dx.doi.org/10.17807/orbital.v4i4.467

Details

Language :
English
ISSN :
19846428
Volume :
4
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Orbital: The Electronic Journal of Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.946055dfba034887bdc361fc42c78aeb
Document Type :
article
Full Text :
https://doi.org/10.17807/orbital.v4i4.467