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Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2
- Source :
- Frontiers in Medicine, Vol 8 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
Details
- Language :
- English
- ISSN :
- 2296858X
- Volume :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9480cce8e8784e2a89ca25e1cef0ccd3
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fmed.2021.585358