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Brief exposure of skin to near-infrared laser augments early vaccine responses

Authors :
Yokomizo Shinya
Katagiri Wataru
Maki Yohei
Sano Tomoya
Inoue Kazumasa
Fukushi Masahiro
Atochin Dmitriy N.
Kushibiki Toshihiro
Kawana Akihiko
Kimizuka Yoshifumi
Kashiwagi Satoshi
Source :
Nanophotonics, Vol 10, Iss 12, Pp 3187-3197 (2021)
Publication Year :
2021
Publisher :
De Gruyter, 2021.

Abstract

Rapid establishment of herd immunity with vaccination is effective to combat emerging infectious diseases. Although the incorporation of adjuvant and intradermal (ID) injection could augment early responses to the vaccine, the current chemical or biological adjuvants are inappropriate for this purpose with their side effects and high reactogenicity in the skin. Recently, a near-infrared (NIR) laser has been shown to augment the immune response to ID vaccination and could be alternatively used for mass vaccination programs. Here, we determined the effect of NIR laser as well as licensed chemical adjuvants on the immunogenicity 1, 2, and 4 weeks after ID influenza vaccination in mice. The NIR laser adjuvant augmented early antibody responses, while the widely used alum adjuvant induced significantly delayed responses. In addition, the oil-in-water and alum adjuvants, but not the NIR laser, elicited escalated TH2 responses with allergenic immunoglobulin E (IgE) responses. The effect of the NIR laser was significantly suppressed in the basic leucine zipper transcription factor ATF-like 3 (Batf3) knockout mice, suggesting a critical role of the cluster of differentiation 103+ (CD103)+ dendritic cells. The current preliminary study suggests that NIR laser adjuvant is an alternative strategy to chemical and biological agents to timely combat emerging infectious diseases. Moreover, its immunomodulatory property could be used to enhance the efficacy of immunotherapy for allergy and cancer.

Details

Language :
English
ISSN :
21928614
Volume :
10
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Nanophotonics
Publication Type :
Academic Journal
Accession number :
edsdoj.96a4bda55fa43cd9e05c3be1853ece1
Document Type :
article
Full Text :
https://doi.org/10.1515/nanoph-2021-0133