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MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

Authors :
Srijayaprakash Babu Uppada
Saiprasad Gowrikumar
Rizwan Ahmad
Balawant Kumar
Bryan Szeglin
Xi Chen
J. Joshua Smith
Surinder K. Batra
Amar B. Singh
Punita Dhawan
Source :
Molecular Cancer, Vol 17, Iss 1, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
BMC, 2018.

Abstract

Abstract Background Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xenopus and Drosophila), a serine/threonine kinase controls the final G2/M checkpoint and prevents premature entry of cells into mitosis. Recent studies suggest that MASTL expression is highly upregulated in cancer and confers resistance against chemotherapy. However, the role and mechanism/s of MASTL mediated regulation of tumorigenesis remains poorly understood. Methods We utilized a large patient cohort and mouse models of colon cancer as well as colon cancer cells to determine the role of Mastl and associated mechanism in colon cancer. Results Here, we show that MASTL expression increases in colon cancer across all cancer stages compared with normal colon tissue (P

Details

Language :
English
ISSN :
14764598
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Molecular Cancer
Publication Type :
Academic Journal
Accession number :
edsdoj.97655b9457e99f01d0d2f6f360d
Document Type :
article
Full Text :
https://doi.org/10.1186/s12943-018-0848-3