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Potential Application of MicroRNAs and Some Other Molecular Biomarkers in Alzheimer’s Disease

Authors :
Olga Paprzycka
Jan Wieczorek
Ilona Nowak
Marcel Madej
Barbara Strzalka-Mrozik
Source :
Current Issues in Molecular Biology, Vol 46, Iss 6, Pp 5066-5084 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Alzheimer’s disease (AD) is the world’s most common neurodegenerative disease, expected to affect up to one-third of the elderly population in the near future. Among the major challenges in combating AD are the inability to reverse the damage caused by the disease, expensive diagnostic tools, and the lack of specific markers for the early detection of AD. This paper highlights promising research directions for molecular markers in AD diagnosis, including the diagnostic potential of microRNAs. The latest molecular methods for diagnosing AD are discussed, with particular emphasis on diagnostic techniques prior to the appearance of full AD symptoms and markers detectable in human body fluids. A collection of recent studies demonstrates the promising potential of molecular methods in AD diagnosis, using miRNAs as biomarkers. Up- or downregulation in neurodegenerative diseases may not only provide a new diagnostic tool but also serve as a marker for differentiating neurodegenerative diseases. However, further research in this direction is needed.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
46
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.97b526962348498a150757c6af1b04
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb46060304