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A new role of growth hormone and insulin growth factor receptor type 1 in neonatal inflammatory nociception
- Source :
- PAIN Reports, Vol 2, Iss 4, p e608 (2017)
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer, 2017.
-
Abstract
- Abstract. Growth hormone (GH) and insulin growth factor 1 (IGF1) are implicated in nociceptive processing; it has been reported that the latter participates in neonatal inflammatory nociception. In the target article, the authors propose that local inflammation evoked by carrageenan administration in mice produces a decrease in the local GH levels and an increment of IGF1 receptors type 1 expression, this produces behavioral nociception and peripheral sensitization that can be prevented by GH systemic administration pretreatment.
- Subjects :
- Anesthesiology
RD78.3-87.3
Subjects
Details
- Language :
- English
- ISSN :
- 24712531 and 00000000
- Volume :
- 2
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- PAIN Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.97dd970b74a54f2e80b544541f48fc34
- Document Type :
- article
- Full Text :
- https://doi.org/10.1097/PR9.0000000000000608