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Effect of pill burden on dosing preferences, willingness to pay, and likely adherence among patients with type 2 diabetes

Effect of pill burden on dosing preferences, willingness to pay, and likely adherence among patients with type 2 diabetes

Authors :
Hauber AB
Han S
Yang JC
Gantz I
Tunceli K
Gonzalez JM
Brodovicz K
Alexander CM
Davies M
Iglay K
Zhang Q
Radican L
Source :
Patient Preference and Adherence, Vol 2013, Iss default, Pp 937-949 (2013)
Publication Year :
2013
Publisher :
Dove Medical Press, 2013.

Abstract

A Brett Hauber,1 Steven Han,2,3 Jui-Chen Yang,1 Ira Gantz,2 Kaan Tunceli,2 Juan Marcos Gonzalez,1 Kimberly Brodovicz,2 Charles M Alexander,2 Michael Davies,2 Kristy Iglay,2 Qiaoyi Zhang,2 Larry Radican2 1Health Preference Assessment, Research Triangle Institute (RTI) Health Solutions, Research Triangle Park, NC, USA; 2Merck Sharp and Dohme Corporation, Whitehouse Station, NJ, USA; 3Temple University, Philadelphia, PA, USA Purpose: To quantify willingness-to-pay (WTP) for reducing pill burden and dosing frequency among patients with type 2 diabetes mellitus (T2DM), and to examine the effect of dosing frequency and pill burden on likely medication adherence. Patients and methods: Participants were US adults with T2DM on oral antihyperglycemic therapy. Each patient completed an online discrete-choice experiment (DCE) with eight choice questions, each including a pair of hypothetical medication profiles. Each profile was defined by reduction in average glucose (AG), daily dosing, chance of mild-to-moderate stomach problems, frequency of hypoglycemia, weight change, incremental risk of congestive heart failure (CHF), and cost. Patients were asked to rate their likely adherence to the profiles presented in each question. Choice questions were based on a predetermined experimental design. Choice data were analyzed using random-parameters logit. Likely treatment adherence was analyzed using a Heckman two-stage model. Results: Of the 1,114 patients who completed the survey, 90 had lower dosing burden (

Subjects

Subjects :
Medicine (General)
R5-920

Details

Language :
English
ISSN :
1177889X
Volume :
2013
Issue :
default
Database :
Directory of Open Access Journals
Journal :
Patient Preference and Adherence
Publication Type :
Academic Journal
Accession number :
edsdoj.97e3e75ba0c14cc5907026179ce857b4
Document Type :
article