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Latex allergy in a dental nurse: Late nasal response is associated with eosinophil recruitment and T helper 2 cell type cytokine mRNA expression
- Source :
- Allergology International, Vol 47, Iss 2, Pp 103-107 (1998)
- Publication Year :
- 1998
- Publisher :
- Elsevier, 1998.
-
Abstract
- The occupational uses of latex gloves may be associated with allergic rhinitis. Hypersensitivity to latex has been shown to be IgE-mediated. However, late nasal responses to latex have not been reported. The present report describes a clinical and immunological study of a dental nurse with work-related rhinitis induced by the use of latex gloves. To examine whether late nasal symptoms were associated with infiltration of T cells and eosinophils and also with preferential expression of T helper 2 (Th2) cell type cytokine mRNA, nasal biopsies were performed before and 24 h after latex provocation and were processed for immunohistology and in situ hybridization. Latex induced early and late nasal responses. After latex provocation, the numbers of T cells and eosinophils were markedly increased compared with number on the control day. In situ hybridization confirmed Th2 type cytokine mRNA expression at 24 h after latex provocation. These results suggest that latex provokes IgE-mediated early and late nasal responses and that late nasal symptoms are associated with an infiltration of T cells and eosinohils and the production of Th2 type cytokines.
Details
- Language :
- English
- ISSN :
- 13238930
- Volume :
- 47
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Allergology International
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.982084ab618c44a99ef8503f8350b9fd
- Document Type :
- article
- Full Text :
- https://doi.org/10.2332/allergolint.47.103