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The effect of dexmedetomidine on expression of neuronal nitric oxide synthase in spinal dorsal cord in a rat model with chronic neuropathic pain

Authors :
Jun Pang
Suming Zhang
Ying Kong
Zhe Wang
Ruomeng Pei
Ping Zhuang
Xiaopeng Wang
Source :
Arquivos de Neuro-Psiquiatria, Vol 81, Iss 03, Pp 233-239 (2023)
Publication Year :
2023
Publisher :
Academia Brasileira de Neurologia (ABNEURO), 2023.

Abstract

Background Neuropathic pain typically refers to the pain caused by somatosensory system injury or diseases, which is usually characterized by ambulatory pain, allodynia, and hyperalgesia. Nitric oxide produced by neuronal nitric oxide synthase (nNOS) in the spinal dorsal cord might serve a predominant role in regulating the algesia of neuropathic pain. The high efficacy and safety, as well as the plausible ability in providing comfort, entitle dexmedetomidine (DEX) to an effective anesthetic adjuvant. The aim of this study was to investigate the effect of DEX on the expression of nNOS in spinal dorsal cord in a rat model with chronic neuropathic pain.

Details

Language :
English
ISSN :
0004282X, 16784227, and 00431761
Volume :
81
Issue :
03
Database :
Directory of Open Access Journals
Journal :
Arquivos de Neuro-Psiquiatria
Publication Type :
Academic Journal
Accession number :
edsdoj.982b2109716d46c7ad33e7744d09c117
Document Type :
article
Full Text :
https://doi.org/10.1055/s-0043-1761491