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The effect of dexmedetomidine on expression of neuronal nitric oxide synthase in spinal dorsal cord in a rat model with chronic neuropathic pain
- Source :
- Arquivos de Neuro-Psiquiatria, Vol 81, Iss 03, Pp 233-239 (2023)
- Publication Year :
- 2023
- Publisher :
- Academia Brasileira de Neurologia (ABNEURO), 2023.
-
Abstract
- Background Neuropathic pain typically refers to the pain caused by somatosensory system injury or diseases, which is usually characterized by ambulatory pain, allodynia, and hyperalgesia. Nitric oxide produced by neuronal nitric oxide synthase (nNOS) in the spinal dorsal cord might serve a predominant role in regulating the algesia of neuropathic pain. The high efficacy and safety, as well as the plausible ability in providing comfort, entitle dexmedetomidine (DEX) to an effective anesthetic adjuvant. The aim of this study was to investigate the effect of DEX on the expression of nNOS in spinal dorsal cord in a rat model with chronic neuropathic pain.
Details
- Language :
- English
- ISSN :
- 0004282X, 16784227, and 00431761
- Volume :
- 81
- Issue :
- 03
- Database :
- Directory of Open Access Journals
- Journal :
- Arquivos de Neuro-Psiquiatria
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.982b2109716d46c7ad33e7744d09c117
- Document Type :
- article
- Full Text :
- https://doi.org/10.1055/s-0043-1761491